Uncoupling Protein-2 Modulates Myocardial Excitation-Contraction Coupling
نویسندگان
چکیده
منابع مشابه
Uncoupling protein-2 modulates myocardial excitation-contraction coupling.
RATIONALE Uncoupling protein (UCP)2 is a mitochondrial inner membrane protein that is expressed in mammalian myocardium under normal conditions and upregulated in pathological states such as heart failure. UCP2 is thought to protect cardiomyocytes against oxidative stress by dissipating the mitochondrial proton gradient and mitochondrial membrane potential (DeltaPsi(m)), thereby reducing mitoch...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2010
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.109.206631